Heart and Soul follows a group of characters and their families, at work and at home, through love, tragedy -and friendship. Clara Casey, consultant cardiologist and separated mother of two, has been hoping for a more glamorous post that this shabby, run-down, inner-city Cardiac Clinic. But she has agreed to do it for a year, and do it she will. Anya had never intended to leave her beloved Poland, but after the love of her life has abandoned her, life seems bleak and empty. Perhaps a new job in a new country will mend her broken heart.