After fifteen years, Dr. Cyrus Mills returns to rural Vermont to inherit the Bedside Manor for Sick Animals, the failing veterinary practice of his recently deceased and long-estranged father. Cyrus, a veterinary pathologist far more comfortable with cold clinical facts than living, breathing animals (not to mention their quirky, demanding owners), intends to sell the practice and get out of town as fast as he can. Then his first patient - a down-on-her-luck golden retriever named Frieda Fuzzypaws - wags her way through the door, and suddenly life gets complicated. With the help of a black Labrador gifted in the art of swallowing underwear, a Persian cat determined to expose her owner's lover as a gold digger, and the allure of a feisty, pretty waitress from the local diner, Cyrus gets caught up in a new community and its endearing residents, both human and animal. Sensing he may have misjudged the past, he begins to realize it's not just his patients that need healing.